Brainstem changes underlie sound sensitivity in fragile X mouse model
Developmental changes in the brainstem driven by fragile X syndrome (FXS)—a condition that often co-occurs with autism spectrum disorder in humans—may underlie the hypersensitivity to sound observed in...
View ArticleScreening could catch a quarter of hip fractures before they happen
Community screening for osteoporosis could prevent more than a quarter of hip fractures in older women - according to new research led by the University of East Anglia (UEA).
View ArticleStudy finds link between fragile X syndrome gene and dysregulated tissue growth
Researchers at Indiana University have found a previously undetected link between the gene that causes fragile X syndrome and increased tissue growth. The link could reveal a key biological mechanism...
View ArticleDelayed development of fast-spiking neurons linked to Fragile X
Northwestern Medicine scientists have discovered a delay in the maturation of fast-spiking neurons in the neonatal cortex of a mouse model of Fragile X syndrome, a human neurodevelopmental disorder.
View ArticleScientists find promise in intervention to normalize biological functions in...
A team of neuroscientists have developed an intervention that normalizes multiple biological functions in mice afflicted with Fragile X Syndrome (FXS). Its breakthrough centers on protein synthesis, or...
View ArticleSelective PDE4D inhibitor shows potential to treat Fragile X autism spectrum...
New preclinical research suggests the potential utility of BPN14770, a selective PDE4D inhibitor currently under development by Tetra Discovery Partners as a prospective treatment for memory and...
View ArticlePotential new treatment for Fragile X targets one gene to affect many
In Fragile X Syndrome—the leading genetic form of intellectual disability and autism—the effects of a single defective gene ripple through a series of chemical pathways, altering signals between brain...
View ArticleNew IOF Compendium documents osteoporosis, its management and global burden
Today, on the occasion of World Osteoporosis Day, the International Osteoporosis Foundation (IOF) has issued the first edition of a comprehensive and scientifically referenced report on osteoporosis.
View ArticleNew role for fragile X protein could offer clues for treatment
The protein behind fragile X syndrome acts as a genetic conductor, orchestrating a symphony of genes that help shape DNA's 3-D structure.
View ArticleNew research on Fragile X syndrome reinforces importance of early detection
Fragile X syndrome—the most common heritable cause of autism spectrum disorder—is something of a phantom. It interferes with the production of a protein critical to synapse formation during a brief...
View ArticleTwo genes help older brain gain new cells
Two genes act as molecular midwives to the birth of neurons in adult mammals and when inactivated in mice cause symptoms of Fragile X Syndrome, a major cause of mental retardation, a new Yale...
View ArticleBrain study reveals clues to treating Fragile X syndrome
Scientists have discovered how the brain can self-correct disruptions in processing, pointing the way towards possible new treatments for autism and intellectual disability.
View ArticleStudy highlights underlying mechanisms of fractures associated with...
There is no disputing that the use of bisphosphonates - with brand names such as Fosamax, Boniva and Reclast - is proven to combat bone loss and fragility fractures in millions of osteoporosis patients...
View ArticleAnimal models can't 'tune out' stimuli, mimicking sensory hypersensitivity in...
By tickling the whiskers of mice, and recording how they respond, UCLA researchers may be closer to understanding why many children with autism cover their ears when they hear loud sounds or can't...
View ArticleDiabetes drug may help symptoms of autism associated condition
A widely used diabetes medication could help people with a common inherited form of autism, research shows.
View ArticleScientists gain insights into how fragile X syndrome disrupts perception
A collaboration between scientists in Belgium, the United States, Norway, France and the UK has resulted in a study that sheds light on the neural mechanisms of fragile X syndrome. This genetic...
View ArticleScientists spot gene for rare disorder causing deafness, blindness
(HealthDay)—Researchers say they have found the genetic cause of a rare disorder that causes children to be born with deafness, blindness, albinism and fragile bones.
View ArticleTreatment window for Fragile X likely doesn't close after childhood
Brain samples from humans show that the treatment window for Fragile X syndrome likely remains open well into maturity after childhood, when previous tests with mice indicated it might close, according...
View ArticleMen face greater risk of death following osteoporosis-related fractures
Men face a greater risk of mortality following a fracture related to osteoporosis, a common disease where the bones become weak and brittle, according to new research presented today at the 2017 Annual...
View ArticleResearchers find promising lead that reduces autism symptoms and more
Fragile X syndrome is the most common cause of autism. Even though the single gene that's responsible for it was discovered in 1991, and the disease is detected by a simple blood test, there's no...
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