Simple, sensitive, and cost-effective assays for analyzing Fragile X-related...
Fragile X syndrome, the most common heritable cause of intellectual disability and a frequent cause of autism, is characterized by abnormalities of the FMR1 gene that are difficult to analyze....
View ArticleRx associated with fracture risk infrequently reduced after fracture occurrence
Is the occurrence of a fragility fracture - where Medicare beneficiaries broke a hip, wrist or shoulder - a missed opportunity to reduce exposure to prescription drugs associated with fracture risk?
View ArticleNew explanation offered for symptoms of fragile X syndrome
Until recently, scientists thought they understood one of the underlying causes of fragile X syndrome, the most common inherited cause of intellectual disability in the United States. The syndrome,...
View ArticleStudy implicates glial cells in fragile X syndrome
Research on fragile X syndrome, the most common inherited cause of mental retardation, has focused mostly on how the genetic defect alters the functioning of neurons in the brain. A new study focusing...
View ArticlePsychologist creates tool for measuring memory
Psychologist Jamie Edgin studies human memory at the University of Arizona, where her research often involves working with very young children and children with intellectual disabilities.
View ArticleIn Singapore, experts seek solutions for the rising burden of osteoporosis in...
The burden of osteoporosis in the Asia-Pacific region is expected to surge in the coming decades. Countries such as Singapore, Japan and Korea are among the high-risk countries for osteoporosis related...
View ArticleStudy shows early brain changes in Fragile X syndrome
A new study led by scientists at The Scripps Research Institute (TSRI) is giving researchers a first look at the early stages of brain development in patients with Fragile X syndrome, a disorder that...
View ArticleMind the (osteoporosis treatment) gap
With the first of the baby boomer generation now entering their eighties, the next decade will see a significant increase in the number of people living with osteoporosis and experiencing the often...
View ArticleParenting significantly affects development of children with Fragile X syndrome
University of Kansas researchers have found that certain specific parenting practices are significantly associated with the development of communication and language skills in children with Fragile X...
View ArticleMajor pledge will boost brain research into causes of autism
Autism will be better understood thanks to a substantial investment from a US philanthropic foundation to the University of Edinburgh.
View ArticleResearchers find promising lead that reduces autism symptoms and more
Fragile X syndrome is the most common cause of autism. Even though the single gene that's responsible for it was discovered in 1991, and the disease is detected by a simple blood test, there's no...
View ArticleMen face greater risk of death following osteoporosis-related fractures
Men face a greater risk of mortality following a fracture related to osteoporosis, a common disease where the bones become weak and brittle, according to new research presented today at the 2017 Annual...
View ArticleTreatment window for Fragile X likely doesn't close after childhood
Brain samples from humans show that the treatment window for Fragile X syndrome likely remains open well into maturity after childhood, when previous tests with mice indicated it might close, according...
View ArticleScientists spot gene for rare disorder causing deafness, blindness
(HealthDay)—Researchers say they have found the genetic cause of a rare disorder that causes children to be born with deafness, blindness, albinism and fragile bones.
View ArticleScientists gain insights into how fragile X syndrome disrupts perception
A collaboration between scientists in Belgium, the United States, Norway, France and the UK has resulted in a study that sheds light on the neural mechanisms of fragile X syndrome. This genetic...
View ArticleDiabetes drug may help symptoms of autism associated condition
A widely used diabetes medication could help people with a common inherited form of autism, research shows.
View ArticleAnimal models can't 'tune out' stimuli, mimicking sensory hypersensitivity in...
By tickling the whiskers of mice, and recording how they respond, UCLA researchers may be closer to understanding why many children with autism cover their ears when they hear loud sounds or can't...
View ArticleStudy highlights underlying mechanisms of fractures associated with...
There is no disputing that the use of bisphosphonates - with brand names such as Fosamax, Boniva and Reclast - is proven to combat bone loss and fragility fractures in millions of osteoporosis patients...
View ArticleBrain study reveals clues to treating Fragile X syndrome
Scientists have discovered how the brain can self-correct disruptions in processing, pointing the way towards possible new treatments for autism and intellectual disability.
View ArticleTwo genes help older brain gain new cells
Two genes act as molecular midwives to the birth of neurons in adult mammals and when inactivated in mice cause symptoms of Fragile X Syndrome, a major cause of mental retardation, a new Yale...
View ArticleNew research on Fragile X syndrome reinforces importance of early detection
Fragile X syndrome—the most common heritable cause of autism spectrum disorder—is something of a phantom. It interferes with the production of a protein critical to synapse formation during a brief...
View ArticleNew role for fragile X protein could offer clues for treatment
The protein behind fragile X syndrome acts as a genetic conductor, orchestrating a symphony of genes that help shape DNA's 3-D structure.
View ArticleNew IOF Compendium documents osteoporosis, its management and global burden
Today, on the occasion of World Osteoporosis Day, the International Osteoporosis Foundation (IOF) has issued the first edition of a comprehensive and scientifically referenced report on osteoporosis.
View ArticlePotential new treatment for Fragile X targets one gene to affect many
In Fragile X Syndrome—the leading genetic form of intellectual disability and autism—the effects of a single defective gene ripple through a series of chemical pathways, altering signals between brain...
View ArticleSelective PDE4D inhibitor shows potential to treat Fragile X autism spectrum...
New preclinical research suggests the potential utility of BPN14770, a selective PDE4D inhibitor currently under development by Tetra Discovery Partners as a prospective treatment for memory and...
View ArticleScientists find promise in intervention to normalize biological functions in...
A team of neuroscientists have developed an intervention that normalizes multiple biological functions in mice afflicted with Fragile X Syndrome (FXS). Its breakthrough centers on protein synthesis, or...
View ArticleDelayed development of fast-spiking neurons linked to Fragile X
Northwestern Medicine scientists have discovered a delay in the maturation of fast-spiking neurons in the neonatal cortex of a mouse model of Fragile X syndrome, a human neurodevelopmental disorder.
View ArticleStudy finds link between fragile X syndrome gene and dysregulated tissue growth
Researchers at Indiana University have found a previously undetected link between the gene that causes fragile X syndrome and increased tissue growth. The link could reveal a key biological mechanism...
View ArticleScreening could catch a quarter of hip fractures before they happen
Community screening for osteoporosis could prevent more than a quarter of hip fractures in older women - according to new research led by the University of East Anglia (UEA).
View ArticleBrainstem changes underlie sound sensitivity in fragile X mouse model
Developmental changes in the brainstem driven by fragile X syndrome (FXS)—a condition that often co-occurs with autism spectrum disorder in humans—may underlie the hypersensitivity to sound observed in...
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